Fig. 18: Plasmon-enhanced photoacoustic bioimaging.

a In vivo photoacoustic imaging enhanced by plasmonic nanorod–melanin hybrids183. Schematic of the gold nanoparticles (AuNPs) and nanorod–melanin hybrids coated with polydopamine (AuNP-PDA). b Comparison of in vivo photoacoustic imaging using AuNPs and AuNP-PDA hybrids as contrast agents. Reproduced with permission183. Copyright 2021 American Chemical Society. c Dual ratiometric SERS and photoacoustic imaging of inflammation -related hydrogen peroxide71. The schematic diagram depicting the utilization of a nanoprobe for SERS imaging and ratiometric PA imaging in the assessment of lipopolysaccharide (LPS)-induced peritonitis. d Ratiometric SERS intensity (I2228/I1418) changes over time. e Photoacoustic imaging at wavelengths of 750 nm and 1250 nm, accompanied by ratiometric photoacoustic imaging, with a scale bar set at 5 mm. Reproduced with permission71. Copyright 2021 John Wiley and Sons.