Fig. 1: A pictorial representation of the difference between OFDM and Zak-OTFS.
From: Low-complexity equalization of Zak-OTFS in the frequency domain

OFDM prevents ISI/ICI, that is the subcarrier spacing is adjusted to avoid interference, while Zak-OTFS embraces ISI/ICI. This results in poor resource utilization in OFDM but low equalization complexity while resource utilization is good in Zak-OTFS at the cost of equalization complexity.