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References
Meuli M, Meuli-Simmen C, Hutchins G M et al. In utero surgery rescues neurological function at birth in sheep with spina bifida. Nature Med 1995; 1: 342–347.
Campbell L R, Dayton D H, Sohal G S . Neural tube defects: A review of human and animal studies on the etiology of neural tube defects. Teratology 1986; 34: 171–187.
Knoblock W H, Layer J M . Retinal detachment and encephalocele. J Pediatr Ophthalmol 1971: 8: 181.
Evrard P, Lyon G, Gadisseux J F . Le developpement prenatal du systeme nerveux et ses perturbations: mecanismes generaus. Progres en neonatologie vol. 4 Basel, NY: Karger, 1984; pp 63–69.
Copp A J, Brook F A, Estibeiro J P, Shum A S W . The embryonic development of mammalian neural tube defects. Prog Neurobiol 1990; 35:363–403.
Hibbard B M . The role of folic acid in pregnancy. J Obstet Gynaecol Brit Commwlth 1964; 71: 529–542.
Smithells R W, Shephard S, Schorah C J et al. Possible prevention of neural-tube defects by periconceptional vitamin supplementation. Lancet 1980; i: 339–340.
Laurence K M, James N, Miller M H et al. Double-blind randomised controlled trial of folate treatment before conception to prevent recurrence of neural-tube defects. Br Med J 1981; 282: 1509–1511.
Laurence K M, James N, Miller M H et al. Increased risk of recurrence of pregnancies complicated by fetal neural tube defects in mothers receiving poor diets, and possible benefit of dietary counselling. Br Med J 1980; 281 1592–1594.
Winship K A, Cahal D A, Weber J C P et al. Maternal drug histories and central nervous system anomalies. Arch Dis Child 1984; 59: 1052–1060.
Mulinare J, Cordero J F, Erickson D et al. Periconceptional use of multivitamins and the occurrence of neural tube defects. JAMA 1988; 260: 3141–3145.
Mills J L, Rhoads G G, Simpson J L et al. The national Institute of Child Health and Human Development Neural Tube Defect Study Group. The absence of a relation between the periconceptional use of vitamins and neural-tube defects. N Engl J Med 1989; 321:430–435.
Bower C, Stanley F J . Dietary folate as a risk factor for neural-tube defects: evidence from a case-control study in Western Australia. Med J Aust 1989; 150: 613–618.
Milunsky A, Jick H, Jick S S et al. Multivitamin/folic acid supplementation in early pregnancy reduces the prevalence of neural tube defects. JAMA 1989; 262: 2847–2852.
Vergel R G, Sanchez L R, Herdero B L et al. Primary prevention of neural tube defects with folic acid supplementation: Cuban experience. Prenat Diagn 1990; 10: 149–152.
MRC Vitamin Study Research Group. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet 1991; 338: 131–137.
Czeizel A E, Dudas I . Prevention of the first occurrence of neural tube defects by periconceptional vitamin supplementation. N Engl J Med 1992; 327: 1832–1835.
Czeizel A E . Prevention of congenital abnormalities by periconceptional multivitamin supplementation. Br Med J 1993; 306: 1645–1648.
Kirke P N, Molloy A M, Daly L E et al. Maternal plasma folate and vitamin B12 are independent risk factors for neural tube defects. Q J Med 1993; 86: 703–708.
Mills J L, McPartlin J M, Kirke P N et al. Homocysteine metabolism in pregnancies complicated by neural-tube defects. Lancet 1995; 345: 149–151.
Steegers-Theunissen R P M, Boers G H J, Trijbels F J M et al. Maternal hyperhomo-cysteinemia: a risk-factor for neural-tube defects? Metabolism 1994; 43: 1475–1480.
Adams M J, Khoury M J, Stevenson R et al. Midtrimester serum methylmalonic acid as a risk marker for neural tube defects. Society for Epidemiologic Research, 1993 Annual Meeting, Keystone, Colorado (abstr).
Goyette P, Sumner J S, Milos et al. Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation identification. Nature Genet 1994; 7: 195–200.
van der Put N, Steegers-Theunissen R P M, Frosst P et al. Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida. Lancet 1995; 346: 1070–1071.
Steegers-Theunissen R P, Boers G H, Trijbels F J et al. Neural-tube defects and derangement of homocysteine metabolism. N Engl J Med 1991; 324: 199–200.
Essien F B, Wannberg S L . Methionine but not folinic acid or vitamin B-12 alters the frequency of neural tube defects in Axd mutant mice. J Nutr 1993; 123: 27–34.
Coelho C N D, Weber J A, Klein N W et al. Whole rate embryos require methionine for neural tube closure when cultured on cow serum. J Nutr 1989; 119: 1716–1725.
Nau H . Valproic acid-induced neural tube defects. Ciba Found Symp (Netherlands) 1994; 181: 144–152.
Seller M J . Vitamins, folic acid and the cause and prevention of neural tube defects. Ciba Found Symp (Netherlands) 1994; 181: 161–173.
Werler M M, Louik C, Shapiro S et al. Ovulation induction and risk of neural tube defects. Lancet 1994; 344: 445–446.
Wald N J . Folic acid and neural tube defects: the current evidence and implications for prevention. In. Neural Tube Defects. Chichester: Wiley, 1994: pp 192–211. (CIBA Foundation Symposium 181).
Expert Advisory Group. Folic acid and the prevention of neural tube defects. Department of Health 1992. Published by Health Publications Unit, Heywood, Lancashire.
Sutcliffe M, Schorah C J, Perry A et al. Prevention of neural tube defects Lancet 1993; 342: 1174.
Clark N A C, Fisk N M . Minimal compliance with the Department of Health recommendation for routine folate prophylaxis to prevent fetal neural tube defects. Br J Obstet Gynaecol 1994; 101: 709–710.
Ministry of Agriculture, Fisheries and Food. Household Food Consumption and Expenditure 1990 London: HMSO, 1991.
Wald N J, Bower C . Folic acid, pernicious anaemia, and prevention of neural tube defects. Lancet 1994: 343: 307.
Wald N J, Bower C . Folic acid and the prevention of neural tube defects. A population strategy is needed. Br Med J 1995; 310: 1019–1020.
Elwood J M, Elwood J H . Epidemiology of Anencephalus and Spina Bifida Oxford University Press: Oxford 1980.
Carstairs V, Cole S . Spina bifida and anencephaly in Scotland. Br Med J 1984; 289: 1182–1184.
Chan A, Robertson E F, Haan E A et al. Prevalence of neural tube defects in South Australia, 1966-91: effectiveness and impact of prenatal diagnosis. Br Med J 1993; 307: 703–706.
Hunt G M . Open spina bifida; outcome for a complete cohort treated unselectively and followed into adulthood. Dev Med Child Neurol 1990; 32: 108–118.
Lorber J . Results of treatment of myelomeningocele. An analysis of 524 unselected cases with special reference to possible selection for treatment. Dev Med Child Neurol 1971; 13: 279–303.
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Minns, R. Folic acid and neural tube defects. Spinal Cord 34, 460–465 (1996). https://doi.org/10.1038/sc.1996.79
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DOI: https://doi.org/10.1038/sc.1996.79
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