Figure 4
From: The precision of axon targeting of mouse olfactory sensory neurons requires the BACE1 protease
Increased presence of APP and APLP2 in olfactory bulbs of BACE1 heterozygous and null mice.
Representative images of immunostaining for APP in olfactory bulbs from littermate wild type (a), BACE1 +/− (b) and BACE1 −/− (c). Quantification of the intensity of immunostaining (d) revealed a significant difference between the BACE1 −/− with either the wild type or BACE 1 +/− mice (n = 3 sets of 3 littermates). A regional analysis of immunostaining (e) in the glomeruli of the olfactory bulb reveals significant increases in APP staining in the ventral and lateral regions. Representative images of immunostaining for APLP2 in olfactory bulbs from littermate wild type (f), BACE1 +/− (g) and BACE1 −/− (h). Quantification of the intensity of immunostaining (i) revealed a significant difference between the BACE1 −/− with either the wild type or BACE 1 +/− mice (n = 3 sets of 3 littermates). A regional analysis of immunostaining (j) in the glomeruli of the olfactory bulb reveals significant increases in APLP2 staining in all 4 regions. * = p < 0.05; ** = p < 0.01.
