Figure 4
From: Network rewiring is an important mechanism of gene essentiality change

Protein complex membership and evolution of gene essentiality changes.
(a) Fraction of genes newly involved in protein complexes are compared in each phenotypic group. (b) Evolutionary rates (dN/dS) of each phenotypic group in yeast. The evolutionary rates (dN/dS) were calculated from nucleotide sequences for 3,392 orthologous open reading frames (ORFs) in four Saccharomyces species including S. cerevisiae, S. paradoxus, S. mikatae and S. bayanus.