Figure 1 | Scientific Reports

Figure 1

From: Characterizing virulence-specific perturbations in the mitochondrial function of macrophages infected with mycobacterium tuberculosis

Figure 1

Mtb-induced ultrastructural changes in the mitochondria of THP-1 cells.

Figure shows representative transmission electron micrographs of mitochondrial morphology in uninfected THP-1 cells (panels A and B) and in cells infected for 24 hrs either with H37Ra (C,D), or with H37Rv (E,F). In the latter cases, the intracellular bacteria are denoted as ‘B’ (panels C and E). Whereas uninfected cells show normal mitochondria, those in H37Ra infected cells showed changed ultrastructure (panels C and D). In H37Rv infected cells, however, the mitochondria were electron dense and elongated (see box in panel E) with prominent cristae (panel F). Mitochondria in panels B, D and F are denoted as ‘M” (scale bar 200 nm), whereas they are identified by arrows in panels A and C. Scale bar for panels A, C and E is 500 nm.

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