Table 1 Parameters used in the model for the three division hypotheses
From: Skin Stem Cell Hypotheses and Long Term Clone Survival – Explored Using Agent-based Modelling
1. Asymmetric division: Stem/TA hypothesis | 2. Populational asymmetry: Clayton et al. (2007)18 | 3. PAS hypothesis: Mascre et al. (2012)20 | |
|---|---|---|---|
Initial seeding | 38 stem cells | 120 progenitor cells | 38 stem cells |
Division: | |||
Stem cell | asymmetric, unlimited | N/A | 10%–80%–10%, unlimited |
Progenitor cell (PC) | symmetric, 3 times | 8%–84%–8%, unlimited | 10%–80%–10%, unlimited |
Division probability: | |||
Non cont inhibit | 0.2 | 0.2 | 0.2 |
Inhibited stem | 0.005 | N/A | 0.001 |
Inhibited PC | 0.015 | 0.015 | 0.01520 |
Quiescent stem | 0.0025 | N/A | 0.000001 |
Quiescent PC | 0.0075 | 0.0075 | 0.0075 |
Division direction: | |||
Stem cell | horizontal | N/A | horizontal |
Progenitor cell | horizontal | horizontal | horizontal |
Adhesion to basement membrane: | |||
Stem cell | strong | N/A | strong |
Progenitor cell | exponentially decreasing with each division44 | strong | strong |
