Figure 1 | Scientific Reports

Figure 1

From: Mining large-scale response networks reveals ‘topmost activities’ in Mycobacterium tuberculosis infection

Figure 1

Modelling the macrophage response in tuberculosis.

(a) A molecular map describing responses triggered in the macrophage upon M.tb infection. A single macrophage is reflected in green and elicits both intracellular (outlined in green) and extracellular (outlined in purple) responses upon encountering either complete mycobacteria or mycobacterial lipids and other components (highlighted in orange). Red arrows represent inhibitory influences, while black arrows indicate activation. (b) Distribution of 1888 proteins in 32 biological modules participating in the cellular response described in (a). Here, the module Cytokine shows highest representation of proteins while VEGF signalling has the least representation, in terms of number of proteins involved in that process.

Back to article page