Figure 3
Transcriptome analysis of hypoxic trophoblasts.
Panel (a). Heatmap constructed using 283 genes upregulated in preeclampsia meta-analysis demonstrating the 65 genes significantly upregulated in hypoxic trophoblasts. Panel (b). GSEA of hypoxic trophoblasts with respect to genes upregulated in preeclampsia. The analysis demonstrates significant correlation (p < 0.001, Enrichment Score = 0.50) between the majority of upregulated genes in preeclampsia and in hypoxic trophoblasts. Panel (c). GO analysis of the gene signature of hypoxic trophoblasts using network visualization and analysis tools (as described in the Methods). Size of the nodes is inversely proportional to the p-values. Groups identified using clustering algorithm are shown in circles, most common GO terms are listed next to the circles. Panel (d). Transcription factor analysis of the genes upregulated in hypoxic trophoblasts using network visualization and analysis tool. Groups identified using clustering algorithm are shown in circles, most common transcription factors are listed next to the circles. Size of the nodes is inversely proportional to the p-value.
