Figure 2
From: CSF1R mutations in hereditary diffuse leukoencephalopathy with spheroids are loss of function
Mutations in the intracellular domain of mCsf1r resulted in either loss of Csf1r signalling or promoted factor independent survival in Ba/F3 cells.
Untransfected Ba/F3 (naïve) or Ba/F3 cells expressing wild-type or mutant mCsf1r were cultured alone or in either IL-3 or rhCSF1. The mean of 3 experiments + SEM is shown. P values were <0.0001 and <0.002 when mutants were compared to wild-type mCsf1r growing in rhCSF1 (*) or in no growth factor (#) respectively.
