Table 3 Motif genes and differential genes identified from the traditional variance analysis. Boldface indicates the genes associated with breast cancer, Boldface and italics indicate the known breast cancer genes
From: Identification of breast cancer patients based on human signaling network motifs
Gene Type | GeneName | Literature Confirmed Rate |
|---|---|---|
85 motif genes | ABL1,AKT1,BAD,BCL2,CASP10,CASP9,CBP,CCNB1,CDK2,CDK5,c-JUN,CREB,CTBP1,EGFR,ERK2,FAS,GEF,Gia,GSK3A,GTP,Hsp90,IKK2,IL12RB2,JAK1,JAK2,JNKK1,MAPK11,MAPK9,MDM2,MAP2K1,MAP2K2,MGLUR1,p14ARF,p38,p53,p65,P73,PAK1,PDGFRA,PKAc,PP2A,RAF1,RAC1,RSK2,SHP1,SHP2,SMAD2,SMAD3,SMAD4,SMO,SRC,SRF,STAT1,STAT3,TCF,TIF2,BAP31,ERBIN,ILK,IRS2,KSR,NCK,PDGFR,PKA,PPP1CC,PPP2R5C,RASGAP,SAM68,TFIIB,BNIP3,FAP-1,FRS2,GRP1,HBEGF,LZK,MLK3,MSK2,SOCS,ARNIP,BPAG2,EPS8,GAB2,HAT1,KRT18,RAP30 | 81.18% |
31 differential genes | ATF3,Catalase,CAVEOLIN,CAV2,CD36,DD,MKP1,EGR1,F3,FHL1,FOS,FOSB,GHR,Gai,NUR77,c-JUN,LEP,LPL,PDE2,PPARG,I1,RIIb,RGS2,TGFBR3,SPRY,HERP1,FIBRONECTIN,Tb,HSP27,Noxa,TopoII | 71% |
