Figure 2 | Scientific Reports

Figure 2

From: Maternal high-fat diet induces hyperproliferation and alters Pten/Akt signaling in prostates of offspring

Figure 2

Gestational high-fat diet stimulates hyperproliferation in the prostate.

(a–f) H & E staining of prostate acini from chow- (a, c and e) and HFD-exposed (b, d and f) offspring at 16 (a and b), 26 (c and d) and 63 (e and f) weeks of age. Insets are high-magnification images to illustrate the most marked morphological defects in prostates from HFD-exposed animals, including tufted (b) and cribriform growth patterns (d and f), but a lack of nuclear atypia. (g) Quantification of the numbers of hyperproliferative acini per slide in prostates from chow- and HFD-exposed offspring at 16, 26 and 63 weeks of age. N ≥ 2 samples per mouse from ≥7 mice, scale bars = 100 μm.

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