Figure 1
From: Characterizing and controlling the inflammatory network during influenza A virus infection
Workflow for characterization and control of the inflammatory networks.
Step 1: Network construction. The framework of the network construction was shown in Supplementary Figure S1. Step 2: Characterizing the inflammatory networks from network structures. Network metrics explored in this study were summarized in Supplementary Figure S2. Step 3: Construction of nonlinear dynamical models for two sub-networks. The problem that identifies the kinetic parameters in the nonlinear models can be converted into an optimization problem by defining a cost function. Step 4: Characterizing the inflammatory networks from dynamics. The procedure for dynamical analysis of the networks was clearly depicted in Supplementary Figure S3. Step 5: Identification of important protein complexes for controlling inflammation.
