Figure 3 | Scientific Reports

Figure 3

From: Mesenchymal morphogenesis of embryonic stem cells dynamically modulates the biophysical microtissue niche

Figure 3

Dynamic modulation of EB mechanical properties.

EBs exhibited differences in (a) viscoelastic creep and (b) modulus after 7 days of differentiation, including (c,d) a significant correlation between modulus and EB diameter within BMP4-treated EBs. In addition, (e) modulus and (f) viscoelastic time constant characteristics were modulated as a function of time, with differences between culture conditions after 14 days of differentiation. (a,b) gray shaded regions represent the upper and lower quartiles while the red center line denotes the median of the populations. (a–d) n = 27 EBs from 5 independent experiments; (e), (f) n = 6 EBs; * = p < 0.05 using two-way ANOVA and post-hoc Tukey analysis.

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