Figure 5 | Scientific Reports

Figure 5

From: Paclitaxel sensitivity in relation to ABCB1 expression, efflux and single nucleotide polymorphisms in ovarian cancer

Figure 5

Association between growth inhibitory effects of paclitaxel and ABCB1 genotypes.

Paclitaxel growth inhibitory effects (IC50) were determined in 19 lymphoblastoid cell lines (a), (c) and (e) and 10 ovarian cancer cell lines (b), (d) and (f), by CellTitre AQueous One Solution Cell Proliferation Assay after 72 hrs drug exposure. ABCB1 genotype was determined by iPLEX genotyping on Sequenom's MassARRAY platform. Associations between IC50 and ABCB1 genotypes at C1236T (a) and (b), G2677T/A (c) and (d) and C3435T (e) and (f) were analysed by Jonckheere-Terpstra test.

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