Figure 4 | Scientific Reports

Figure 4

From: Apoptosis Therapy in Cancer: The First Single-molecule Co-activating p53 and the Translocator Protein in Glioblastoma

Figure 4

Dissociation of recombinant MDM2/p53 complex by NMR studies.

One-dimensional proton spectrum of the side chains of tryptophans (W) of p53 alone (a), MDM2/p53 complex (b), MDM2/p53 complex after addition of compound 7 (c), or compound 1 (d). Figure shows the 1H NMR signals of the tryptophan residues of p53 and of MDM2/p53 complex (0.1 mM, only W53 NHε side chains signal can be detected in the last). After the addition of compound 7 or 1 (0.2 mM formal final concentration) to the MDM2/p53 complex, the W23 peak appears (c and d, respectively) indicating a complete p53 release.

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