Figure 6
The functional effect of mirtazapine for antimetastatic potential in human metastatic cancer cells.
Typical results of the invasiveness assays for SAS-H1 (a) and G-361 (b) cells are indicated. The number of mirtazapine-treated cells entering the pores decreases significantly (P < 0.05, Mann-Whitney U test) compared with the control cells. Original magnification, ×100; scale bars, 100 μm. (c), (d) Migration assay of mirtazapine-treated cells. The wound area in cultured mirtazapine-treated cells has significantly (P < 0.05, Mann-Whitney U test) decreased, whereas there is a gap in the control cells. Original magnification, ×100; scale bars, 100 μm. Mir (−) = without mirtazapine; Mir (+) = with mirtazapine.
