Figure 11
From: Tumor regression achieved by encapsulating a moderately soluble drug into a polymeric thermogel
Myelosuppression after medication of IRN with or without thermogel.
WBC number per liter blood in Kunming mice (capable of normal immune system) bearing murine solid tumor S180 after injecting IRN or IRN/thermogel with the same drug dose (45 mg/kg). The p values from t-tests are 0.007 and 0.047 between the IRN and IRN/thermogel groups at day 2 and day 8, respectively. Injection of NS was set as the negative control of myelosuppression. At day 8, the p values between IRN or IRN/thermogel and the NS group are 0.045 and 0.677, respectively. The animal numbers of n are as follows: 10 for the group of NS, 10 for IRN/thermogel (day 2), 10 for IRN (day 2), 6 for IRN/thermogel (day 5), 4 for IRN (day 5), 9 for IRN/thermogel (day 8) and 10 for IRN (day 8).
