Figure 4
From: Tumor regression achieved by encapsulating a moderately soluble drug into a polymeric thermogel
Characterization of the triblock copolymer of PLGA-PEG-PLGA synthesized in this study.
(a) Phase diagram of PLGA-PEG-PLGA aqueous solutions with and without drug loading (IRN, 4 mg/mL). The medium was normal saline. (b) Typical images of the sol and gel states of 20 wt% PLGA-PEG-PLGA aqueous solutions containing 4 mg/mL IRN at the indicated temperatures. (c) Storage modulus G′ and loss modulus G″ of 20 wt% polymer solutions with and without drug loading (IRN, 4 mg/mL). Oscillatory frequency ω: 10 rad/s; Heating rate: 0.5°C/min. (d) Temperature-dependent distributions of hydrodynamic diameters of micelles in 0.1 wt% PLGA-PEG-PLGA aqueous solutions with and without drug loading (IRN, 0.02 mg/mL).
