Figure 5
From: Tumor regression achieved by encapsulating a moderately soluble drug into a polymeric thermogel
Degradation of 20 wt% PLGA-PEG-PLGA thermogel in PBS.
(a) Photographs of thermogels in tubes at indicated degradation time in vitro. The volume of PBS was 10 mL in the upper medium per vial with 0.5 mL 20 wt% polymer solution in the bottom. The PBS was refreshed every 4 days. (b) GPC curves of materials at various degradation times. The mobile phase for GPC was tetrahydrofuran with a flow rate of 1 mL/min. (c) Change of Mw of the copolymer and molar ratio of LA/GA during degradation. Mw0 and Mw, the weight-average molecular weight of polymer at day 0 and in degradation, respectively; the values were determined from GPC. The LA/GA molar ratios were obtained from 1H NMR. (d) pH value of the PBS medium and weight percentage of thermogel remaining during degradation.
