Figure 3 | Scientific Reports

Figure 3

From: Intravenous immunoglobulin-induced IL-33 is insufficient to mediate basophil expansion in autoimmune patients

Figure 3

Effect of IVIg on the IL-33 production from DC-SIGN+ human innate cells.

(a and b) Histograms showing the expression of DC-SIGN by healthy donor's monocyte-derived human dendritic cells (Mo-DCs) and splenocytes. (c) IVIg does not induce IL-33 from DC-SIGN+ human innate cells. Mo-DCs or human splenocytes (n = 5 donors) were exposed to IVIg either under non-inflammatory conditions or under inflammatory conditions (TLR-stimuli or inflammatory cytokine cocktail) for 48 hours. IL-33 in the culture supernatants was analyzed by ELISA.

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