Figure 4
From: A miR-199a/miR-214 Self-Regulatory Network via PSMD10, TP53 and DNMT1 in Testicular Germ Cell Tumor
PSMD10 negatively regulates the expression of TP53 in TGCT.
(A) PSMD10 mRNA expression and (B) PSMD10 protein level in HT and NT2 cells. (C) PSMD10 mRNA expression in normal testis tissues and embryonal carcinoma. (D) PSMD10 mRNA expression and (E) PSMD10 protein level after transfection of siPSMD10 into NT2 cells. (F) TP53 mRNA expression and (G) TP53 protein level after transfection of siPSMD10 into NT2 cells. (H) PSMD10 and TP53 mRNA levels inversely correlated in clinical samples (r = −0.409, p = 0.042). Statistical analysis to evaluate correlation was performed using Pearson's correlation analysis.
