Table 1 Summary of results of molecular dynamics calculations comparing the archaeal with the human chaperonin at 37 and 42°C

From: A human CCT5 gene mutation causing distal neuropathy impairs hexadecamer assembly in an archaeal model

  

  Shape response to temperature (°C)

Chaperonin

Structure

37

42

PfCD

Ile138 (wt)

Stable (rigid)

Change (flexible)

 

Arg138 (pathogenic mutant equivalent)

Stable (rigid)

Stable (rigid)

 

His138 (humanized mutant)

Change (flexible)

Change (flexible)

CCT5

His147 (wt)

Change (flexible)

Stable (rigid)

 

Arg147 (pathogenic mutant)

Stable (rigid)

Change (flexible)

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