Figure 3
From: Dissecting the Human Protein-Protein Interaction Network via Phylogenetic Decomposition
Interaction density and preference across age groups.
(a) The interaction density within (upper row) and between (indexed grid) age groups. Color intensity (red-to-green) reflects the relative magnitude of cell values (high-to-low). (b) The interaction preference (empirical Z scores, estimated by network randomization) within and between age groups. (c) Interaction patterns for a new hypothetical age group (Group 7) under the random duplication model (left) versus the perturbation avoidance model (right). Perturbation avoidance was implemented by setting the duplicate retention probability of a node inversely proportional to its degree centrality. (d) Composition of paralogous genes in the human genome. A total of n = 211 paralogous groups were extracted from NCBI HomoloGene.
