Figure 2
From: Are polymorphisms of the immunoregulatory factor CD40LG implicated in acute transfusion reactions?
Genomic structure of the CD40LG and the haplotype blocks of the French (FR) and Tunisian (TN) populations (this study) compared with those of JPT, CEU, YRI and TSI (HapMap data).
(a) Genomic structure of the CD40LG gene and the position of the identified polymorphisms. Exons are represented by boxes, with filled boxes denoting translated regions. Upward facing lines indicate amplified fragments and polymorphisms are shown as red stars for SNPs and purple lozenges for microsatellites. (b) CD40LG LD and haplotype diversity in French and Tunisian populations. (c) CD40LG LD and haplotype diversity in JPT, CEU, YRI and TSI populations. The numbers in boxes represent the pairwise D’ value between adjacent SNPs. For (b) and (c), haplotype frequencies are shown below the LD diagrams. Triangular pointers highlight SNPs which could be tagged for future association analysis.
