Figure 1

Proteins with RHIM-related motifs.
(A): multiple sequence alignment of representative RHIM domains of human (hs), drosophila (dm) and branchiostoma (BF) proteins and prion-forming domain of P. anserina protein. Human and drosophila proteins are denoted by their gene names, branchiostoma proteins by their genome ORF number. Residues invariant or conservatively replaced in at least 50% of all sequences are shown on black and grey background, respectively. (B): Domain architecture of the same proteins, RHIM domains are shown in orange, NACHT-type ATPase domains in blue, death domains in cyan, repeat domains in green, transmembrane region in brown and all other domains in grey.