Figure 4
From: Survival analysis of infected mice reveals pathogenic variations in the genome of avian H1N1 viruses
The HA variants associated with pathogenicity of avian H1N1 IAVs by residue and host effect.
(a) Ribbon model of the HA1 (teal) and HA2 (green) dimer in a single HA molecule from A/mallard/Alberta/35/1976 [PDB: 2WRH]. Antigenic sites Sa (peach), Ca (yellow), Sb (dark blue) and Cb (orange) and locations of variants (magenta) are indicated. (b) The variants S203 and T173 in HA of avian H1N1 IAVs are located in the head of HA, as part of the Sb (dark blue) and Sa (peach) antigenic sites, respectively. These variants play a role in host immune response. These positions were based on the sequences used in this study.
