Figure 4 | Scientific Reports

Figure 4

From: Over expression of hRad9 protein correlates with reduced chemosensitivity in breast cancer with administration of neoadjuvant chemotherapy

Figure 4

Knockdown of hRad9 in breast cancer cells enhances sensitivity to doxorubicin treatment.

Knockdown of hRad9 enhanced the doxorubicin-induced growth inhibitory effects on MCF-7 (a) and MDA-MB-231(b) breast cancer cells. IC50 value to doxorubicin in hRad9 knockdown breast cancer cells MCF-7 (c) and MDA-MB-231 (d) was significantly decreased comparing with that of the blank controls(P < 0.001) or scrambled negative siRNA (P < 0.001 and P < 0.005, respectively, each experiment was performed three times).

Back to article page