Table 2 POI-related index in each group

From: Hyaluronic acid prevents immunosuppressive drug-induced ovarian damage via up-regulating PGRMC1 expression

Groups

N

Estrous cycle

Numbers of follicles

Ovarian index

Uterine index

E2 concentration

normal

delayed

irregular

primordial

primary

secondary

antral

Control

7

7

0

0

2149 ± 200.1

914 ± 61.75

400 ± 37.7

176 ± 12.7

0.5039 ± 0.07390

1.7352 ± 0.5105

47.685 ± 7.3

Model

7

0

3

4

2165 ± 137.9

799 ± 55.7

298 ± 27.5*

88 ± 6.4*

0.2837 ± 0.05620*

1.3102 ± 0.2129*

29.623 ± 1.22*

HA

7

7

0

0

1920 ± 108.2

743 ± 35.1

445 ± 52.7#

114 ± 14.1#

0.4665 ± 0.08582#

1.9767 ± 0.4006#

62.785 ± 13.58#

  1. Note: Ovarian index = Bilateral ovarian wet weight (mg)/Body weight (g) × 100%, Uterine index = uterus wet weight (mg)/Body weight (g) × 100%.
  2. E2 concentration: pg/ml.
  3. *P < 0.05 vs. control group;
  4. #P < 0.05 vs. model group.
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