Table 1 Phenotype of mice after 16 weeks' consumption of control or high-fat diet. CD control diet; HFD high-fat diet. Results are shown as mean ± SEM and n = 5–9 per group. Metabolic and physical parameters are indicated as mean per day ± SEM. P values are obtained with two-way ANOVA. Simple main effects analysis with Bonferroni correction was conducted if there was a significant interaction effect (genotype × diet), after which: ap < 0.001 compared to WT mice fed HFD

From: Fat mass- and obesity-associated gene Fto affects the dietary response in mouse white adipose tissue

    

p values

  

Wild type

Fto-knockout

Effect of genotype

Effect of diet

Genotype × diet

Final weight

CD

31.5 ± 1.09a

28.2 ± 1.06

<0.001

<0.001

0.001

(g)

HFD

45.4 ± 1.07

32.3 ± 1.64a

   

Water intake

CD

3.74 ± 0.34

3.03 ± 0.26

0.35

<0.001

0.14

(mL day-1)

HFD

2.28 ± 0.26

2.45 ± 0.22

   

Energy intake

CD

62.7 ± 2.8

67.0 ± 5.3

0.33

0.77

0.82

(kJ day-1)

HFD

59.6 ± 7.9

66.7 ± 3.8

   

Heat production

CD

95.3 ± 2.1

96.3 ± 1.7

0.79

0.12

0.99

(kJ h-1 day-1)

HFD

100.8 ± 3.7

101.7 ± 3.7

   

Heat production per weight

CD

3.30 ± 0.11

3.56 ± 0.22

0.40

<0.001

0.36

(kJ h-1 g-1 day-1)

HFD

2.64 ± 0.15

2.63 ± 0.11

   

Respiratory exchange rate

CD

45.1 ± 0.71

45.1 ± 1.03

0.53

<0.001

0.48

(VCO2 VO2-1 day-1)

HFD

37.9 ± 0.62

38.8 ± 0.37

   

Ambulatory movement

CD

8429 ± 1577

10098 ± 1190

0.79

0.01

0.24

(counts day-1)

HFD

6596 ± 593

5527 ± 951

   

Fine movement

CD

6546 ± 1169

7829 ± 774

0.66

0.09

0.30

(counts day-1)

HFD

5927 ± 400

5395 ± 790

   

Total movement

CD

17480 ± 1312

17927 ± 1948

0.90

<0.001

0.81

(counts day-1)

HFD

12523 ± 970

12386 ± 821

   
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