Table 1 Treatment of CORT (40 mg/kg, s.c.) for 7 days altered sleep parameters in rats

From: Glucocorticoid receptors in the locus coeruleus mediate sleep disorders caused by repeated corticosterone treatment

 

Vehicle

CORT (40 mg/kg, s.c., 7 days)

Total sleep (min)

247.2 ± 6.6

198.0 ± 3.8**

NREM sleep (min)

230.2 ± 6.5

170.1 ± 4.6**

 Light sleep (min)

227.7 ± 6.5

169.4 ± 7.2**

 Slow wave sleep (min)

8.0 ± 2.9

4.7 ± 1.6

REM sleep (min)

18.2 ± 1.5

27.8 ± 1.5*

Sleep latency (min)

25.9 ± 3.6

48.1 ± 4.1**

REM sleep latency (min)

32.7 ± 4.9

6.9 ± 1.2**

Light sleep (%)

92.1 ± 3.7

85.6 ± 3.5

Slow wave sleep (%)

3.3 ± 1.2

2.3 ± 0.8

REM sleep (%)

7.3 ± 0.5

14.0 ± 1.8**

  1. Data are represented as mean ± S.E.M. (n = 8 ~ 9/group); *p < 0.05 and **p < 0.01 vs vehicle (Student's t-test).
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