Table 2 Potential target overlaps among five herbs of Wu-tou decoction (WTD)
Herbs in WTD | Target name | Target symbol | Known drug | Indication | Target classification |
|---|---|---|---|---|---|
Radix Aconiti | Nuclear factor NF-kappa-B | NFKB2 | Curaxin CBLC102; GMX1777; PG-490-88; Sulfasalizine; Tyloxapol; | rheumatoid arthritis | Clinical trial target |
Radix Astragali | Transcription factor AP-1 | JUN | T-5224 | rheumatoid arthritis | Clinical trial target |
Radix Aconiti | Metabotropic glutamate receptor 1 | GRM1 | AZD-9272; AZD8529; PF-1913539; | pain | Clinical trial target |
Radix Astragali/Radix Aconiti | T-cell surface glycoprotein CD4 | CD4 | Blinatumomab;Anti-CD4 | rheumatoid arthritis | Clinical trial target |
Radix Aconiti | Beta-2 nAChR | CHRNB2 | ABT-894 | pain | Discontinued target |
Radix Aconiti | Muscarinic acetylcholine receptor M1 | CHRM1 | Benztropine; Biperiden; Clidinium; Cycrimine; Darotropium; Darotropium + 642444; Dicyclomine; Ethopropazine; GSK1034702; GSK573719; GSK961081; Glycopyrrolate; Oxyphenonium; Pirenzepine; Propantheline; Revatropate; Sabcomeline hydrochloride; Talsaclidine fumarate; Talsaclidine isomer; Trihexyphenidyl; Xanomeline tartrate; | pain | Successful target |
Radix Aconiti | Muscarinic acetylcholine receptor M3 | CHRM3 | Cevimeline; Darifenacin; Diphemanil Methylsulfate; LAS-34273; Oxybutynin; Revatropate; Solifenacin; Succinylcholine; Tiotropium; Tolterodine; | pain | Successful target |
Raidix Paeoniae Alba/Herba Ephedrae | Prostaglandin G/H synthase 1 | PTGS1 | Suprofen; Salsalate | rheumatoid arthritis and osteoarthritis | Successful target |
Raidix Paeoniae Alba/Herba Ephedrae | COX-2 | PTGS2 | Tolmetin;Tiaprofenic acid | pain and rheumatoid arthritis | Successful target |
Radix Glycytthizae/Radix Astragali/Radix Aconiti | Aldose reductase | AKR1B1 | Zenarestat;Sulindac | rheumatoid arthritis | Successful target |
Radix Aconiti | Mu-type opioid receptor | OPRM1 | Alfentanil; Alvimopan; Anileridine; Buprenex; Buprenorphine; Diphenoxylate; Fentanyl; GNTI; GSK1521498; LY-25582; Levomethadyl Acetate; Methadyl Acetate; Methylnaltrexone; Naloxone; Oxymorphone; Remifentanil; TD-1211; Tramadol ER; | pain | Successful target |
Radix Aconiti | Kappa-type opioid receptor | OPRK1 | Asimadoline; Dezocine; GNTI; | pain | Successful target |
Radix Aconiti | Delta-type opioid receptor | OPRD1 | BIO-306; Butorphanol; Codeine; Divers drug; Hydrocodone; Hydromorphone; Loperamide; Nalbuphine; Naltrexone; Oxycodone; | pain | Successful target |
Radix Aconiti | Voltage-gated sodium channel subunit alpha Nav1.8 | SCN10A | SPI-860; Tetracaine | pain | Successful target |
Radix Aconiti | Tachykinin 1 receptor | TACR1 | AZD2624; Aprepitant; CS-003; Casopitant; DA-5018; DNK-333; Ezlopitant; GSK 679769; GSK1144814; GSK424887; L-759274; Orvepitant; R 673; SLV-317; SLV-323; TAK-637; Vestipitant; Zunrisa/Rezonic; | pain | Successful target |
Raidix Paeoniae Alba/Radix Glycytthizae/Radix Astragali/Herba Ephedrae/Radix Aconiti | Bile acid receptor | NR1H4 | Guggulsterone | osteoarthritis | Successful target |
Radix Astragali/Herba Ephedrae/Radix Aconiti | Glucocorticoid receptor | NR3C1 | Amcinonide; Betamethasone; Budesonide; Dexamethasone; Flunisolide; Fluorometholone; Fluticasone; Fluticasone Propionate; GW685698X; GW870086X; ISIS-GCCRrx; Loteprednol Etabonate; Medrysone; Methylprednisolone; Mometasone; ORG 34517/34850; Prednisone; | rheumatoid arthritis | Successful target |
Radix Aconiti | Cannabinoid receptor 1 | CNR1 | AVE1625; AZD1175; AZD1704; AZD1940; AZD2207; CB1 antagonist; CBD cannabis derivative; CP-945598; Dianicline+rimonabant; JD-5037; KDS-2000; Marinol; Rimonabant; Rimonbant; SLV-319; TM38837; Taranabant; Tebipenem; ZY01; | pain | Successful target |
Radix Aconiti | Neuronal acetylcholine receptor subunit alpha-2 | CHRNA2 | Carbachol; Decamethonium; Doxacurium chloride; Levallorphan; Metocurine; Metocurine Iodide; Mivacurium; Pipecuronium; Rocuronium; Tubocurarine; Vecuronium; | pain | Successful target |
Radix Aconiti | Interleukin-1 beta | IL1B | Canakinumab; Celastrol; Gallium nitrate; Glucosamine; Ibudilast; | osteoarthritis | Successful target |
Raidix Paeoniae Alba/Radix Glycytthizae/Herba Ephedrae | Tumor necrosis factor | TNF | Etanercept/Adalimumab/Infliximab/ | rheumatoid arthritis | Successful target |
Herba Ephedrae | Voltage-dependent N-type calcium channel subunit alpha-1B | CACNA1B | Cilnidipine; Ralfinamide; Ziconotide; | pain | Successful target |
