Table 1 [3H]AziPm binding to rat brain regions

From: Macroscopic and Macromolecular Specificity of Alkylphenol Anesthetics for Neuronal Substrates

Brain region

0.1 μM [3H]AziPm (mO.D. ± SE)a

0.1 μM [3H]AziPm + 300 μM propofol (mO.D. ± SE)

AziPm selectivity ratiob

Halothane selectivity ratioc

Cortex

215 ± 9

199 ± 11

0.14

0.13

Corpus callosum

147 ± 11

151 ± 7

0.10

0.12

Hippocampal molecular layer

199 ± 12

190 ± 11

0.13

0.13

Hippocampal pyramidal layer

168 ± 7

157 ± 7

0.11

0.10

Dentate molecular layer

212 ± 12

198 ± 7

0.14

0.12

Dentate granule cell layer

145 ± 7

141 ± 6

0.10

0.07

Cerebellar molecular layer

182 ± 6

178 ± 6

0.12

0.14

Cerebellar granular layer

118 ± 5

125 ± 2

0.08

0.07

Cerebellar white matter

100 ± 7

97 ± 5

0.07

0.12

  1. aMilli-optical density (mO.D.) data is from (n = 4) brain sections for [3H]AziPm and (n = 8) sections for [3H]AziPm + propofol.
  2. bSelectivity ratio calculated as region mO.D./sum of mO.D. from all the regions.
  3. cData for halothane derived from Ref. 8.
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