Figure 6 | Scientific Reports

Figure 6

From: Curcumin Pyrazole and its derivative (N-(3-Nitrophenylpyrazole) Curcumin inhibit aggregation, disrupt fibrils and modulate toxicity of Wild type and Mutant α-Synuclein

Figure 6

Representative AFM images showing aggregate morphology of WtAS in the presence of compounds 1, 3, 6 and 15.

WtAS (210 µM) was co-incubated with equimolar concentration of compound 1, 3, 6 and 15 for 30 days. The ability of these compounds to prevent aggregation was visualised by AFM. Representative AFM topographic images of ultrastructure of 50X diluted WtAS (210 µM) aggregates (a) alone at day 30 (b) compound 1 (c) compound 3 (d) compound 6 (e) compound 15. Right panel shows the histogram analysis depicting size distribution.

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