Table 1 HBV DNA methylation in various HBV-infected livers by BS-PCR sequencing.

From: Comprehensive DNA methylation analysis of hepatitis B virus genome in infected liver tissues

Percent of methylated CpG sites €

CpG island

1

2

3

Hepatitis

6.6% (5/76)

6.0% (15/250)

17.5% (16/91)

Cirrhosis

0% (0/60)

0.8% (2/236)

10.8% (7/65)

HCC

16.1% (20/124)

8.0% (32/398)

52.5% (75/143)

p value# HCC vs. (Hepatitis and Cirrhosis)

0.0007

0.0046

<0.0001

  1. €The percent of methylated CpG sites was calculated as the number of methylated CpG sites detected / total CpG sites with valid BS sequencing data (methylated + unmethylated) shown in Fig. 2.
  2. #Fisher’s two-tailed exact test.
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