Figure 2
iPSC-MSCs-CdM transplantation attenuates Dox-induced cardiomyopathy in mice.
a) Schematic chart showing induction of Dox-induced cardiomyopathy in mice and transplantation of BM-MSC-CdM or iPSC-MSC-CdM. b) Representative echocardiography photographs showing heart function in Control and Dox group at 0 week (i). Compared with control group, left ventricular ejection fraction (LVEF), fractional shortening (FS) and +dP/dt were dramatically reduced in the Dox group (ii,iii,iv) (*p < 0.01 vs. Control group). c) Representative PV-Loop photographs showing heart function in different groups at 3 weeks. d) Effects of BM-MSCs-CdM or iPSC-MSCs-CdM on left ventricular (LV) function assessed 3 weeks after CdM injection using cardiac catheterization. Left ventricular systolic pressure (LVSP); End systolic pressure volume relationship (ESPVR)(ii); and +dP/dt (iii) (*p < 0.01 vs. Control group; #p < 0.01 vs. Dox group; †p < 0.01 vs. BM-MSCs-CdM group). e) J curve showing +dp/dt among different groups at 0 weeks and 3 weeks respectively (*p < 0.01 vs. Dox 0 weeks).
