Figure 3 | Scientific Reports

Figure 3

From: Potent Paracrine Effects of human induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells Attenuate Doxorubicin-induced Cardiomyopathy

Figure 3

iPSC-MSCs-CdM transplantation reverses Dox-induced histological change in mice.

a) At 3 weeks after CdM injection, histological examination with Hematoxylin and eosin staining for heart tissue among different groups (i–iv). Gross view of heart tissue among Control (i), Dox treated (ii), BM-MSCs-CdM (iii) and iPSC-MSCs-CdM (iv) treated mice. Compared with control mice (i), enlarged left ventricular cavity in doxorubicin treated mice was observed (ii). Sirius red staining showed a different myocardium fibrosis among experimental groups (v–viii). b) Quantitative measurement of fibrosis ratio of heart among different experimental groups (*p < 0.01 vs. Control group; #p < 0.01 vs. Dox group; †p < 0.01 vs. BM-MSCs-CdM group).

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