Figure 4 | Scientific Reports

Figure 4

From: Potent Paracrine Effects of human induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells Attenuate Doxorubicin-induced Cardiomyopathy

Figure 4

iPSC-MSCs-CdM transplantation ameliorates ROS generation and apoptosis of cardiomyocytes induced by Dox in the heart tissue of mice.

a) At 3 weeks after CdM injection, the concentration of MDA among different groups was measured (*p < 0.01 vs. Control group; #p < 0.01 vs. Dox group; †p < 0.01 vs. BM-MSCs-CdM group, n = 3). b) Representative photographs showing differential accumulation of TUNEL positive cells among Control, Dox, BM-MSCs-CdM treatment (BM-MSCs-CdM), or iPSC-MSCs-CdM treatment (iPSC-MSCs-CdM) group. c) Quantitative measurement of the apoptotic rate of myocardium was expressed as percent of positive TUNEL cells vs. total DAPI positive cells per viewing area (*p < 0.01 vs. Control group; #p < 0.01 vs. Dox group; †p < 0.01 vs. BM-MSCs-CdM group, n = 6).

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