Figure 7 | Scientific Reports

Figure 7

From: Potent Paracrine Effects of human induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells Attenuate Doxorubicin-induced Cardiomyopathy

Figure 7

Immunodepletion of MIF and GDF-15 in iPSC-MSCs-CdM fails to rescue the Dox-induced cardiomyopathy.

a) Different cardioprotective effects of iPSC-MSCs-CdM or iPSC-MSCs-CdM-MIF/GDF-15(−) or MIF/GDF-15 transplantation on LV geometry and function, including LVSP (i), +dp/dt (ii) and ESPVR (iii) assessed 3 weeks after CdM injection using cardiac catheterization (*p < 0.01 vs. Control group; #p < 0.01 vs. Dox group; †p < 0.01 vs. iPSC-MSCs-CdM group; $p < 0.01 vs. iPSC-MSCs-CdM group n = 6). b) Sirius red staining showing a different myocardium fibrosis among Control group (i); Dox group (ii); iPSC-MSCs-CdM (iii) group; iPSC-MSCs-CdM-MIF/GDF(−) group (iv); MIF/GDF-15 (v). Quantitative measurement of fibrosis of heart among different experimental groups (v) (*p < 0.01 vs. Control group; #p < 0.01 vs. Dox group; †p < 0.01 vs. iPSC-MSCs-CdM group, n = 6; $p < 0.01 vs. iPSC-MSCs-CdM group n = 6).

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