Table 1 Top 10 secreted factors over-represented in iPSC-MSCs.
Secreted factors | mRNA Refseq | P-value | Mean ratio (iPSC-MSCs/BM-MSCs) | Involved biological process |
|---|---|---|---|---|
MIF | NM_002415 | 0.0007 | 9.0226 | Inflammatory response, apoptosis, cell proliferation, oxidation |
EMAP-II | NM_004757 | 0.0048 | 8.4005 | Apoptosis, inflammatory response, cell migration, cell proliferation |
GDF-15 | NM_004864 | 0.0046 | 7.4638 | inflammation, apoptosis, PI3K/AKT signaling, Angiogenesis, cardioprotective properties, tissue differentiation |
Osteoprotegerin | NM_002546 | 0.0024 | 7.2562 | Apoptosis, OPG/RANK/RANKL axis |
PDGF-AA | NM_002607 | 0.003 | 5.0133 | Response to endogenous stimulus, inflammatory response, cell migration, cell proliferation |
FGF-16 | NM_003868 | 0.0024 | 4.9466 | Actin cytoskeleton, MAPK signaling pathway, glycoprotein, response to abiotic stimulus, |
GFR alpha-4 | NM_022139 | 0.005 | 4.1354 | Lipoprotein, glycoprotein, signal |
Thrombospondin-1 | NM_003246 | 0.0029 | 3.9156 | Apoptosis, cell migration, inflammatory response, cell proliferation |
IL-24 | NM_006850 | 0.0021 | 3.7026 | Apoptosis |
ErbB3 | NM_001005915 | 0.0016 | 3.701 | Apoptosis, response to endogenous stimulus, cell proliferation |
