Figure 7 | Scientific Reports

Figure 7

From: Mechanical overloading causes mitochondrial superoxide and SOD2 imbalance in chondrocytes resulting in cartilage degeneration

Figure 7

Antioxidant treatment effectively normalizes mitochondrial superoxide generation in wild-type articular chondrocytes in vivo.

Superoxide generation in chondrocytes isolated from the tibial plateau of wild-type cartilage after the intra-articular injection of 1% APPS for 24 h was analyzed via flow cytometry. APPS or PBS was injected into the joint cavity on the DMM side in wild-type mice at 2 weeks after DMM surgery (n = 3, *P < 0.05 versus control, Student’s t-test).

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