Figure 1
From: Azithromycin inhibits IL-1 secretion and non-canonical inflammasome activation
Azithromycin specifically inhibits IL-1β secretion upon LPS stimulation in human monocytes.
Panel a)-d) show the impact of azithromycin on cytokine release of LPS or flagellin stimulated human monocytes. Cells were treated with the indicated concentrations of azithromycin and stimulated with either 100 ng/ml LPS or 100 ng/ml Flagellin for 20 h. After co-incubation, cell culture supernatants were analysed for the presence of the indicated cytokines by Luminex®. Values are expressed as mean ± SEM from 6 independent experiments. *Significant compared to LPS/flagellin alone, p < 0.05 calculated by paired t-test.
