Figure 3 | Scientific Reports

Figure 3

From: Uric Acid Produces an Inflammatory Response through Activation of NF-κB in the Hypothalamus: Implications for the Pathogenesis of Metabolic Disorders

Figure 3

Icv administration of UA induces hypothalamic inflammation.

(A–C) UA concentration in the CSF (A), the amount of UA in hypothalamic tissue (B) and fasting serum UA concentration (C) were determined in rats fed chow or a HUAD for up to 3 months. (D–I) Time course of the induction of mRNA expression of the inflammatory mediators Tnfa (D), Il6 (E), Il1b (F), Nfkbia (G), Ikbkb (H) and Ikbke (I) in the hypothalamus of the rats that received icv administration of saline or 3000 ng/ml UA for up to 2 weeks (n = 6 rats per group). All mRNA species were quantified relative to Gapdh housekeeping gene expression and are presented as fold changes relative to saline controls [fold of control]. All displayed values are the mean ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001 versus normal saline control.

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