Table 1 Familial cancer risks conferred by affected parents and siblings.

From: Population Landscape of Familial Cancer

Cancer site

Patients with negative family history

1 parent affected

1 parent (age limited) affected1

1 sibling affected

p-value for difference between RRsib and RRPar2

N3

RR4

95% CI5

N

RR

95% CI

N

RR

95% CI

Upper aerodigestive tract

7236

136

1.51

(1.13–2.02)

113

1.57

(1.14–2.15)

56

1.73

(1.10–2.72)

0.72

Esophagus

2248

26

2.45

(1.55–3.90)

18

2.33

(1.34–4.05)

12

3.36

(1.70–6.62)

0.41

Stomach

4411

222

1.72

(1.47–2.02)

172

1.78

(1.49–2.13)

46

2.97

(2.11–4.18)

0.0090

Small intestine

1489

17

4.81

(2.99–7.75)

14

5.34

(3.16–9.01)

14

10.11

(5.98–17.09)

0.09

Colorectum

25187

2945

1.72

(1.64–1.80)

2100

1.80

(1.71–1.90)

905

2.00

(1.84–2.17)

0.0294

Liver

4625

130

1.61

(1.29–1.99)

101

1.78

(1.39–2.27)

30

2.07

(1.32–3.23)

0.56

Pancreas

5152

178

1.96

(1.66–2.33)

140

2.09

(1.73–2.54)

54

2.73

(2.01–3.71)

0.15

Lung

18111

1346

1.86

(1.74–1.99)

1108

1.92

(1.78–2.07)

712

2.50

(2.28–2.74)

<.0001

Breast

56566

6102

1.73

(1.67–1.80)

4989

1.78

(1.70–1.85)

3493

1.84

(1.75–1.94)

0.24

Cervix

8074

128

1.57

(1.28–1.93)

122

1.59

(1.29–1.96)

54

2.03

(1.48–2.78)

0.21

Endometrium

9298

301

2.21

(1.88–2.61)

257

2.37

(1.98–2.83)

128

2.13

(1.66–2.73)

0.49

Ovary

8633

261

2.52

(2.20–2.88)

241

2.67

(2.32–3.07)

122

2.97

(2.44–3.61)

0.38

Prostate

37805

6622

2.10

(2.03–2.18)

4469

2.33

(2.24–2.43)

3390

2.59

(2.48–2.72)

0.0005

Testis

6652

32

3.90

(2.63–5.79)

32

3.96

(2.67–5.86)

82

6.94

(5.42–8.89)

0.0173

Kidney

7739

201

1.58

(1.34–1.87)

175

1.68

(1.40–2.01)

75

2.09

(1.59–2.75)

0.18

Urinary bladder

10944

513

1.76

(1.56–1.98)

370

1.84

(1.61–2.12)

172

1.90

(1.55–2.32)

0.81

Melanoma

22807

763

2.43

(2.23–2.66)

643

2.55

(2.32–2.81)

584

2.74

(2.48–3.03)

0.31

Skin, squamous cell

8369

426

2.07

(1.86–2.29)

189

2.16

(1.85–2.52)

104

2.25

(1.83–2.77)

0.75

Nervous system

19099

371

1.54

(1.35–1.75)

349

1.58

(1.38–1.80)

215

1.71

(1.44–2.03)

0.45

Thyroid gland

4791

90

5.13

(3.91–6.74)

87

5.61

(4.25–7.40)

48

5.43

(3.74–7.87)

0.86

Endocrine glands

7810

130

2.05

(1.61–2.62)

110

1.99

(1.53–2.59)

60

1.98

(1.38–2.83)

0.98

Non–Hodgkin lymphoma

11895

276

1.61

(1.41–1.84)

203

1.65

(1.41–1.93)

124

1.69

(1.38–2.06)

0.85

Hodgkin lymphoma

3931

19

2.57

(1.65–3.98)

18

2.59

(1.65–4.07)

40

9.60

(7.08–13.00)

<.0001

Myeloma

3296

61

2.12

(1.64–2.74)

40

1.96

(1.43–2.68)

22

2.73

(1.79–4.18)

0.21

Leukemia

12149

277

1.86

(1.62–2.14)

216

1.88

(1.61–2.20)

105

2.17

(1.73–2.71)

0.31

  1. 1Individuals were only considered to have a positive family history if the parental cancer was diagnosed at age ≤ 78 years.
  2. 2Risk estimates for limited parental age were considered for comparison.
  3. 3N = Number of cases with a concordant cancer in the family.
  4. 4RR = Relative risk.
  5. 5CI = Confidence interval.
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