Table 3 Analysis of clinical conditions in patients with different FBN1 genotypes.

From: Wide mutation spectrum and frequent variant Ala27Thr of FBN1 identified in a large cohort of Chinese patients with sporadic TAAD

Mutation Type

Age (yr) at diagnosis

Maximum aortic diameter (mm)

Aortic dissection (n=)

AR (n=)

MVR (n=)

TVR (n=)

BAV (n=)

Cys missense (n = 5)

44.0 ± 11.7

49.3 ± 9.7

3

4

2

2

1

Non-Cys missense (n = 13)

48.7 ± 12.0

53.9 ± 12.6

7

9

3

6

0

Disruptive (n = 5)

35.8 ± 4.09

70.8 ± 18.5*

4

3

2

2

0

  1. Note: The data in the first two columns were analyzed by one-way ANOVA with Bonferroni post-test (*p < 0.05). The data in the rest five columns were analyzed by Fisher test. AR, aortic regurgitation; MVR, mitral valve regurgitation; TVR, tricuspid valve regurgitation; BAV, bicuspid aortic valve., between the disruptive mutation group and non-Cys missense mutation group.
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