Table 4 Comparison of clinical parameters of patients with and without FBN1 mutations.

From: Wide mutation spectrum and frequent variant Ala27Thr of FBN1 identified in a large cohort of Chinese patients with sporadic TAAD

Mutation Type

Age (y) at diagnosis

Maximum aortic diameter (mm)

Aorticdissection(n=)

AR(n=)

MVR(n=)

TVR(n=)

BAV(n=)

Patients with hypertension(n=)

FBN1-positive (n = 23)

44.9 ± 11.6

57.0 ± 15.4

14

16

7

10

1

7 (30.4%)

FBN1-negative (n = 123)

51.6 ± 13.6*

54.4 ± 12.9

78

75

31

23

10

77 (62.6%)*

  1. Note: AR, aortic regurgitation; MVR, mitral valve regurgitation; TVR, tricuspid valve regurgitation; BAV, bicuspid aortic valve. Data in the first two columns were analyzed by Student t test. Data in the rest of six columns were analyzed by Chi-square test. *p < 0.05.
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