Figure 1
From: The Architecture of the TIR Domain Signalosome in the Toll-like Receptor-4 Signaling Pathway
Toll-like receptor pathway (adapted from literature12,15,19), in traditional node-and-edge representation, where nodes represent proteins and edges represent interactions between proteins.
TLR pathway is complicated and has many branches. Stimulation of TLRs propagate the signal through two parallel paths: MyD88-dependent path (green), which leads to production of pro-inflammatory cytokines and TRIF-dependent path (orange), which gives rise to transcription of antiviral proteins—interferons—and anti-inflammatory cytokine IL-10. MyD88-mediated pathway also has three branches, namely TRAF6- (green), TRAF3- (orange) (downstream of endosomal TLRs) and FADD-dependent (pink) downstream pathways. For space limitation, we showed TLRs on endosomal membrane as monomers, but they also dimerize upon stimulation.
