Figure 3
From: The Architecture of the TIR Domain Signalosome in the Toll-like Receptor-4 Signaling Pathway
TLR4 homodimer models.
(a) Back-to-back TLR4 dimer (BB). (b) Face-to-face TLR4 dimer (FF), which is very similar a previously suggested TLR4-dimer model21 and crystal structure of the dimeric TIR domain of IL-1RAPL (1t3g.pdb)42. (c) Another face-to-face dimer (FF2) in which BB-loops are in very close proximity. The box in the lower left corner shows the structural alignment of this TLR4-homodimer model with the one that is obtained by superimposition of TLR4 with TLR2 homodimer crystal structure (1o77_CD), (146 of 276 residues with 0.73 RMSD by multiport). Cyan color is TLR4 TIR domain, red-labeled regions are BB-loops and yellow spheres are C747 residues on each TLR4 TIR domain, which are suggested to be involved in the interface. The dark blue dimer in the box is TLR4-dimer, which is obtained by superimposition with TLR2 dimer (1o77_CD).
