Figure 4
From: The Architecture of the TIR Domain Signalosome in the Toll-like Receptor-4 Signaling Pathway
Interaction models of Mal-monomer (a,c) and Mal-dimer (b,d) with BB and FF TLR4-homodimer models. Yellow protein is Mal and green spheres show the proposed interface residues of Mal (R184, A185, Y187)27, none of which are at the correct site in the monomeric-Mal-TLR interaction model. However, if dimerization of Mal is also taken into account, it is seen that both monomers are in contact with TLR4, one of which has the interface residue at the correct site.
