Figure 7 | Scientific Reports

Figure 7

From: The Architecture of the TIR Domain Signalosome in the Toll-like Receptor-4 Signaling Pathway

Figure 7The alternative text for this image may have been generated using AI.

MyD88 interaction models with the downstream orchestrators reveal that the three parallel downstream paths are competitive.

(a) TRAF6 (1lb5:A) and TRAF3 (1fll:A) binds to almost completely overlapping interfaces on MyD88 DD (3mop:F), thus they are mutually exclusive. (b) IRAK4 (3mop:J) and FADD (2gf5:A) bind to overlapping interfaces on MyD88 DD (3mop:F), thus they compete to bind to MyD88. MyD88-IRAK4 interaction is not PRISM prediction, where the crystal structure of the complex is available (3mop:FJ). Red box indicates the location of steric clash.

Back to article page